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Journal article

Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine

Abstract:

Neisseria meningitidis is a major cause of meningitis and septicaemia. A MenB vaccine (4CMenB) was licensed by the European Medicines Agency in January 2013. Here we describe the blood transcriptome and proteome following infant immunisations with or without concomitant 4CMenB, to gain insight into the molecular mechanisms underlying post‐vaccination reactogenicity and immunogenicity. Infants were randomised to receive control immunisations (PCV13 and DTaP‐IPV‐Hib) with or without 4CMenB at 2...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/msb.20209888

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
ORCID:
0000-0002-6902-9886
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
ORCID:
0000-0001-9456-5712
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More from this funder
Name:
FP7 Ideas: European Research Council (FP7 Ideas)
Publisher:
EMBO Press
Journal:
Molecular Systems Biology More from this journal
Volume:
16
Issue:
11
Article number:
e9888
Place of publication:
England
Publication date:
2020-11-19
Acceptance date:
2020-10-08
DOI:
EISSN:
1744-4292
Language:
English
Keywords:
Pubs id:
1146039
Local pid:
pubs:1146039
Deposit date:
2020-11-21

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