Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors.
Vascular development begins when mesodermal cells differentiate into endothelial cells, which then form primitive vessels. It has been hypothesized that endothelial-specific gene expression may be regulated combinatorially, but the transcriptional mechanisms governing specificity in vascular gene expression remain incompletely understood. Here, we identify a 44 bp transcriptional enhancer that is sufficient to direct expression specifically and exclusively to the developing vascular endotheli...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date: