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A simple backscattering microscope for fast tracking of biological molecules.

Abstract:

Recent developments in techniques for observing single molecules under light microscopes have helped reveal the mechanisms by which molecular machines work. A wide range of markers can be used to detect molecules, from single fluorophores to micron sized markers, depending on the research interest. Here, we present a new and simple objective-type backscattering microscope to track gold nanoparticles with nanometer and microsecond resolution. The total noise of our system in a 55 kHz bandwidth...

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Publication status:
Published

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Publisher copy:
10.1063/1.3495960

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Role:
Author
Journal:
The Review of scientific instruments
Volume:
81
Issue:
11
Pages:
113704
Publication date:
2010-11-05
DOI:
EISSN:
1089-7623
ISSN:
0034-6748
URN:
uuid:d42a8d0d-9b9e-410a-a34d-06deb5421a70
Source identifiers:
103645
Local pid:
pubs:103645

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