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Journal article

Amino acid sensing and mTOR regulation: inside or out?

Abstract:

mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell. This is reflected in the impact of aberrant mTOR signalling on a number of major human diseases and has helped to drive research to understand how TOR (target of rapamycin) is itself regulated. While it is clear that amino acids can affect TOR signalling, how these molecules are sensed by TOR remains...

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Publication status:
Published

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Publisher copy:
10.1042/bst0370248

Authors


Goberdhan, DC More by this author
Ogmundsdóttir, MH More by this author
Reynolds, B More by this author
Visvalingam, SM More by this author
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Journal:
Biochemical Society transactions
Volume:
37
Issue:
Pt 1
Pages:
248-252
Publication date:
2009-02-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:d41d32fb-ac56-467a-9484-b37fda167ae7
Source identifiers:
114041
Local pid:
pubs:114041

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