Journal article icon

Journal article

Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses.

Abstract:

Lentivectors stimulate potent immune responses to antigen transgenes and are being developed as novel genetic vaccines. To improve safety while retaining efficacy, we constructed a lentivector in which transgene expression was restricted to antigen-presenting cells using the mouse dectin-2 gene promoter. This lentivector expressed a green fluorescent protein (GFP) transgene in mouse bone marrow-derived dendritic cell cultures and in human skin-derived Langerhans and dermal dendritic cells. In...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/jvi.01289-07

Authors


Dewannieux, M More by this author
Gileadi, U More by this author
Expand authors...
Journal:
Journal of virology
Volume:
82
Issue:
1
Pages:
86-95
Publication date:
2008-01-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:d40a6712-005c-49d9-a502-368ee939bd82
Source identifiers:
34018
Local pid:
pubs:34018

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP