Bone marrow transplantation in multiple sclerosis.

Journal article

There is strong circumstantial evidence that multiple sclerosis (MS) is an autoimmune disease. Nonspecific immunosuppressive therapy has not been successful in altering the natural course of the illness. Bone marrow transplantation has heretofore been a radical therapy used in patients with life-threatening malignancies but has potential as a treatment for human autoimmunity. In MS there have been no controlled studies. We report here four patients with MS undergoing bone marrow transplantati...

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Authors: Mandalfino, P; Rice, G; Smith, A; Klein, J; Rystedt, L

• Publication status: Published
• Journal: Journal of neurology
• Volume: 247
• Issue: 9
• Pages: 691-695
• Publication date: 2000-09-01
• DOI: 10.1007/s004150070112
• EISSN: 1432-1459
• ISSN: 0340-5354
• Language: English
• Keywords: Middle Aged; Adult; Prognosis; Treatment Outcome; Humans; Multiple Sclerosis; Neoplasms; Disease Progression; Female; Bone Marrow Transplantation; Comorbidity; Male