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Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion.

Abstract:

BACKGROUND: Acute tryptophan depletion lowers brain serotonin synthesis and results in a transient, but striking, clinical relapse in recovered depressed patients. AIMS: To identify brain regions which change their activity as an acute depressive relapse evolves and to determine how pathological mood might modulate neural activity during a cognitive task. METHOD: We used H2(15)O positron-emission tomography (PET) to study eight recovered depressed men after tryptophan depletion and after a co...

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Publication status:
Published

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Publisher copy:
10.1192/bjp.174.6.525

Authors


Morris, JS More by this author
Friston, KJ More by this author
Journal:
The British journal of psychiatry : the journal of mental science
Volume:
174
Issue:
6
Pages:
525-529
Publication date:
1999-06-05
DOI:
EISSN:
1472-1465
ISSN:
0007-1250
URN:
uuid:d403d714-0a53-4617-8391-1e341079429f
Source identifiers:
185769
Local pid:
pubs:185769

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