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Journal article

Synthesis and physical properties of anti-HIV antisense oligonucleotides bearing terminal lipophilic groups.

Abstract:
A number of phosphoramidite monomers have been prepared and used in the synthesis of antisense phosphorothioate oligonucleotides bearing 5'-polyalkyl and cholesterol moieties. Similar groups have also been attached to the 3'-end of oligonucleotides by means of functionalised CPG. Melting temperatures of duplexes formed between phosphorothioate oligonucleotides with lipophilic end-groups and complementary DNA strands were found to be identical to those formed by the equivalent unmodified phosphorothioates.
Publication status:
Published

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Publisher copy:
10.1093/nar/20.13.3411

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Nucleic acids research More from this journal
Volume:
20
Issue:
13
Pages:
3411-3417
Publication date:
1992-07-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:400091
UUID:
uuid:d3fe9502-df5c-43ce-8420-52a2cd451eb9
Local pid:
pubs:400091
Source identifiers:
400091
Deposit date:
2013-11-16

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