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Journal article

Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL.

Abstract:

The FOXP1 forkhead transcription factor is targeted by recurrent chromosome translocations in several subtypes of B-cell non-Hodgkin lymphomas, where high-level FOXP1 protein expression has been linked to a poor prognosis. Western blotting studies of diffuse large B-cell lymphoma (DLBCL) cell lines unexpectedly identified the atypical high-level expression of 2 smaller, 60 to 65 kDa, FOXP1 isoforms in all 5 of those with the activated B cell (ABC)-like DLBCL subtype and in a subgroup of prima...

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Publication status:
Published

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Journal:
Blood
Volume:
111
Issue:
5
Pages:
2816-2824
Publication date:
2008-03-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:d3fe5078-c3dc-45f1-9263-161b1d661255
Source identifiers:
121000
Local pid:
pubs:121000

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