Journal article
An artificial vector model for generating abnormal electrocardiographic rhythms
- Abstract:
- We present generalizations of our previously published artificial models for generating multi-channel ECG to provide simulations of abnormal cardiac rhythms. Using a three-dimensional vectorcardiogram (VCG) formulation, we generate the normal cardiac dipole for a patient using a sum of Gaussian kernels, fitted to real VCG recordings. Abnormal beats are specified either a perturbations to the normal dipole or as new dipole trajectories. Switching between normal and abnormal beat types is achieved using a first-order Markov chain. Probability transitions can be learned from real data or modeled by coupling to heart rate and sympathovagal balance. Natural morphology changes from beat-to-beat are incorporated by varying the angular frequency of the dipole as a function of the inter-beat (RR) interval. The RR interval time series is generated using our previously described model whereby time- and frequency-domain heart rate (HR) and heart rate variability characteristics can be specified. QT-HR hysteresis is simulated by coupling by Gaussian kernels associated with the T-wave in the model with a nonlinear factor related to the local HR (determined from the last n RR intervals). Morphology changes due to respiratory frequency. We demonstrate an example of the use of this model by switching HR-dependent T-wave alternans (TWA) with and without phase-switching due to ectopy. Application of our model also reveals previously unreported effects of common TWA estimation methods.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 762.1KB, Terms of use)
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- Publisher copy:
- 10.1088/0967-3334/31/5/001
- Publisher:
- Institute of Physics (IOP) Publishing
- Journal:
- Physiological Measurement More from this journal
- Volume:
- 31
- Issue:
- 5
- Pages:
- 595-609
- Publication date:
- 2010-01-01
- Edition:
- Accepted Manuscript
- DOI:
- EISSN:
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1361-6579
- ISSN:
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0967-3334
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:d3f17fd3-c872-4fa1-b7e3-a1158821ab78
- Local pid:
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ora:5073
- Deposit date:
-
2011-03-01
Terms of use
- Copyright holder:
- Institute of Physics and Engineering in Medicine
- Copyright date:
- 2010
- Notes:
- This is an author-created, un-copyedited version of an article accepted for publication in the journal of Physiological Measurement. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at http://dx.doi.org/10.1088/0967-3334/31/5/001.
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