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Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.

Abstract:

Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major hist...

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Publication status:
Published

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Publisher copy:
10.1038/ng.960

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Journal:
Nature genetics More from this journal
Volume:
43
Issue:
11
Pages:
1139-1141
Publication date:
2011-11-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Keywords:
Pubs id:
pubs:187621
UUID:
uuid:d3e6a267-eb0b-481e-84d6-c4707fde4cc9
Local pid:
pubs:187621
Source identifiers:
187621
Deposit date:
2012-12-19

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