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Journal article

Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy.

Abstract:

Clinicians currently use simple cut-points, such as serum prostate-specific antigen (PSA) >or=4 ng/ml, to decide whether to recommend further work-up for prostate cancer (PCa). As an alternative strategy, we evaluated multivariable models giving probabilities of a PCa diagnosis based on PSA and several circulating novel biomarkers. We measured total PSA, free PSA (fPSA), fPSA subfractions (single-chain fPSA-I and multichain fPSA-N), total human glandular kallikrein 2 (hK2) and full-length ...

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Publisher copy:
10.1002/ijc.22427

Authors


Steuber, T More by this author
Vickers, A More by this author
Kattan, MW More by this author
Eastham, JA More by this author
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Journal:
International journal of cancer. Journal international du cancer
Volume:
120
Issue:
7
Pages:
1499-1504
Publication date:
2007-04-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:d3df7798-acc0-4d6d-9a5a-6fbc333472cc
Source identifiers:
365955
Local pid:
pubs:365955

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