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T cell antigen receptor activation and actin cytoskeleton remodeling.

Abstract:

T cells constitute a crucial arm of the adaptive immune system and their optimal function is required for a healthy immune response. After the initial step of T cell-receptor (TCR) triggering by antigenic peptide complexes on antigen presenting cell (APC), the T cell exhibits extensive cytoskeletal remodeling. This cytoskeletal remodeling leads to the formation of an "immunological synapse" [1] characterized by regulated clustering, segregation and movement of receptors at the interface. Syna...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Biochimica et biophysica acta
Volume:
1838
Issue:
2
Pages:
546-556
Publication date:
2014-02-05
DOI:
EISSN:
1879-2642
ISSN:
0006-3002
URN:
uuid:d3de8891-caaa-469a-b7a1-49480c32a1b2
Source identifiers:
426233
Local pid:
pubs:426233

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