T cell antigen receptor activation and actin cytoskeleton remodeling.
T cells constitute a crucial arm of the adaptive immune system and their optimal function is required for a healthy immune response. After the initial step of T cell-receptor (TCR) triggering by antigenic peptide complexes on antigen presenting cell (APC), the T cell exhibits extensive cytoskeletal remodeling. This cytoskeletal remodeling leads to the formation of an "immunological synapse"  characterized by regulated clustering, segregation and movement of receptors at the interface. Syna...Expand abstract
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