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Dynamic tuneable G protein-coupled receptor monomer-dimer populations

Abstract:

G protein-coupled receptors (GPCRs) are the largest class of membrane receptors, playing a key role in the regulation of processes as varied as neurotransmission and immune response. Evidence for GPCR oligomerisation has been accumulating that challenges the idea that GPCRs function solely as monomeric receptors; however, GPCR oligomerisation remains controversial primarily due to the difficulties in comparing evidence from very different types of structural and dynamic data. Using a combinat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-03727-6

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Funding agency for:
Castell, O
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Funding agency for:
Watts, A
Grant:
G0900076/1
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
1710
Publication date:
2018-04-27
Acceptance date:
2018-03-06
DOI:
ISSN:
2041-1723
Source identifiers:
844911
Keywords:
Pubs id:
pubs:844911
UUID:
uuid:d3d6cddc-d5f8-4531-a34f-7cae52654a59
Local pid:
pubs:844911
Deposit date:
2018-04-30

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