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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

Abstract:

The pathological end-state of Parkinson disease is well described from postmortem tissue, but there remains a pressing need to define early functional changes to susceptible neurons and circuits. In particular, mechanisms underlying the vulnerability of the dopamine neurons of the substantia nigra pars compacta (SNc) and the importance of protein aggregation in driving the disease process remain to be determined. To better understand the sequence of events occurring in familial and sporadic P...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1309143110

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Parkinson's UK More from this funder
Wellcome Trust More from this funder
Medical Research Council More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
110
Issue:
42
Pages:
E4016-E4025
Publication date:
2013-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d3d3a410-bd4a-4420-a50d-8c4fc7a36fe0
Source identifiers:
430799
Local pid:
pubs:430799

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