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Journal article

Impact of pre-adapted HIV transmission

Abstract:

Human leukocyte antigen class I (HLA)-restricted CD8(+) T lymphocyte (CTL) responses are crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of viral escape mutants remains unclear, as these variants can also reduce intrinsic viral fitness. To address this, we here developed a metric to determine the degree of HIV adaptation to an HLA profile. We demonstrate that transmission of viruses that are pre-adapted to the HLA molecules expressed in the recipient i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nm.4100

Authors


Carlson, JM More by this author
Pfeifer, N More by this author
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Funding agency for:
Goulder, PJ
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Medicine Journal website
Volume:
22
Issue:
6
Pages:
606-613
Publication date:
2016-06-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pubs id:
pubs:623451
URN:
uri:d3ce89b0-8466-46f7-bc04-9a81c8d80774
UUID:
uuid:d3ce89b0-8466-46f7-bc04-9a81c8d80774
Local pid:
pubs:623451
Language:
English
Keywords:

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