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Is narcolepsy an antibody-mediated autoimmune disease

Abstract:

Narcolepsy is a lifelong sleep disorder of unknown cause. Patients experience excessive daytime sleepiness (EDS) in conjunction with the pathognomonic symptom of cataplexy, which is a sudden bilateral loss of motor tone triggered by positive emotion. Central to the pathology of narcolepsy-cataplexy is the loss of orexin-secreting neurons in the hypothalamus and the concomitant loss of orexin neuropeptide in the cerebrospinal fluid (CSF). The cause is thought to be autoimmune, mainly becaus...

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Institution:
University of Oxford
Research group:
Neuroimmunology
Oxford college:
Worcester College
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:d3c58629-a54a-4d1f-8fb9-01c8048f35f1
Local pid:
ora:9994

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