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Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.

Abstract:

BACKGROUND: We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter region was methylated in colonic tumour samples. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the methylation profile of the two CpG islands present in the promoter region of SGK1 in a panel of 5...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0013840

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Institution:
University of Oxford
More by this author
Institution:
University of Oxford
de Palo, M More by this author
Macarone Palmieri, R More by this author
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Nuffield Department for Clinical Medicine More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
11
Pages:
Article: e13840
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:d3c303e4-2381-4ff9-926a-4356e3e6e4b2
Source identifiers:
97255
Local pid:
pubs:97255

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