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Histamine - Binding proteins in tick saliva

Abstract:

Ticks, like other haematophagous ectoparasites, secrete in their saliva bioactive substances that counter the host animal's defence reactions at the feeding site and thus facilitate the acquisition of the bloodmeal. We discovered a family of histamine-binding proteins (HBPs) in the saliva of the brown ear tick, Rhipicephalus appendiculatus. HBPs most probably act by mopping up free histamine at the wound site, making it unavailable to the host's H1- and H2-histamine receptors, thus suppressin...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
FASEB JOURNAL
Volume:
12
Issue:
5
Pages:
A1001-A1001
Publication date:
1998-03-20
ISSN:
0892-6638
URN:
uuid:d3b90ecf-c4b1-41ad-958b-e8fbf07dac54
Source identifiers:
18869
Local pid:
pubs:18869
Language:
English

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