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Suppression of collagen-induced arthritis by continuous administration of IL-4.

Abstract:

The onset of collagen-induced arthritis in DBA/1 mice is accompanied by a predominantly Th1 response, characterized by production of the proinflammatory cytokines IFN-gamma and TNF-alpha, and a predominance of IgG2a anti-collagen Abs. This study has primarily addressed the effects of continuous administration of exogenous IL-4, a Th2 cytokine, on collagen-induced arthritis in terms of time of onset, clinical symptoms, and histologic changes compared with those in untreated controls. The contr...

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Publication status:
Published

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Authors


Horsfall, AC More by this author
Butler, DM More by this author
Marinova, L More by this author
Warden, PJ More by this author
Williams, RO More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
159
Issue:
11
Pages:
5687-5696
Publication date:
1997-12-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:d3b88a14-53e3-4e7e-ad39-fb327c147999
Source identifiers:
481600
Local pid:
pubs:481600

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