- Abstract:
-
The onset of collagen-induced arthritis in DBA/1 mice is accompanied by a predominantly Th1 response, characterized by production of the proinflammatory cytokines IFN-gamma and TNF-alpha, and a predominance of IgG2a anti-collagen Abs. This study has primarily addressed the effects of continuous administration of exogenous IL-4, a Th2 cytokine, on collagen-induced arthritis in terms of time of onset, clinical symptoms, and histologic changes compared with those in untreated controls. The contr...
Expand abstract - Publication status:
- Published
- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 159
- Issue:
- 11
- Pages:
- 5687-5696
- Publication date:
- 1997-12-05
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:d3b88a14-53e3-4e7e-ad39-fb327c147999
- Source identifiers:
-
481600
- Local pid:
- pubs:481600
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Suppression of collagen-induced arthritis by continuous administration of IL-4.
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