Journal article icon

Journal article

Aggrecanases and cartilage matrix degradation.

Abstract:

The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu373-Ala374 bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in rheumatoid arthritis and in osteoarthritis. Three members of the ADAMTS family of proteinases, ADAMTS-1, ADAMTS-4 and ADAMTS-5, have been identified as aggrecanases. Matrix metalloproteinases, which are also foun...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1186/ar630

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Kashiwagi, M More by this author
Journal:
Arthritis research and therapy
Volume:
5
Issue:
2
Pages:
94-103
Publication date:
2003
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:d3b65fab-6693-4a07-b42e-c8bad1c55e1a
Source identifiers:
226786
Local pid:
pubs:226786

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP