- Abstract:
-
The human PrP gene (PRNP) has two common alleles that encode either methionine or valine at codon 129. This polymorphism modulates disease susceptibility and phenotype of human transmissible spongiform encyphalopathies, but the molecular mechanism by which these effects are mediated remains unclear. Here, we compared the misfolding pathway that leads to the formation of beta-sheet-rich oligomeric isoforms of the methionine 129 variant of PrP to that of the valine 129 variant. We provide evide...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m401754200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 279
- Issue:
- 30
- Pages:
- 31390-31397
- Publication date:
- 2004-07-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:d3b3a6ca-7c6e-406b-9e4f-778abbd488b7
- Source identifiers:
-
22358
- Local pid:
- pubs:22358
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant: implications for disease susceptibility to Creutzfeldt-Jakob disease.
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