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Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis)

Abstract:

BACKGROUND: Melioidosis, caused by infection with Burkholderia (B.) pseudomallei, is a severe illness that is endemic in Southeast Asia. Osteopontin (OPN) is a phosphorylated glycoprotein that is involved in several immune responses including induction of T-helper 1 cytokines and recruitment of inflammatory cells. METHODOLOGY AND PRINCIPAL FINDINGS: OPN levels were determined in plasma from 33 melioidosis patients and 31 healthy controls, and in wild-type (WT) mice intranasally infected with...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Volume:
4
Issue:
8
Pages:
e1000920
Publication date:
2010-08-31
Acceptance date:
2010-07-30
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Language:
English
Keywords:
UUID:
uuid:d39f96c5-d033-4a6e-a593-6b1abf30e9b0
Local pid:
pubs:71328
Source identifiers:
71328
Deposit date:
2012-12-19

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