- Abstract:
-
Cortical interneurons in rodents are generated in the ventral telencephalon and migrate tangentially into the cortex. This process requires the coordinated action of many intrinsic and extrinsic factors. Here we show that Robo1 and Robo2 receptor proteins are dynamically expressed throughout the period of corticogenesis and colocalize with interneuronal markers, suggesting that they play a role in the migration of these cells. Analysis of Robo mutants showed a marked increase in the number of...
Expand abstract - Publisher copy:
- 10.1016/j.ydbio.2007.10.052
-
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- Journal:
- Developmental biology
- Volume:
- 313
- Issue:
- 2
- Pages:
- 648-658
- Publication date:
- 2008-01-05
- DOI:
- EISSN:
-
1095-564X
- ISSN:
-
0012-1606
- URN:
-
uuid:d3994a35-c530-46df-bfea-7eef7af2b2a2
- Source identifiers:
-
324263
- Local pid:
- pubs:324263
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons.
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