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Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

Abstract:

Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some of those in a third sample of European ancestry (n ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.573

Authors


Thorgeirsson, TE More by this author
Gudbjartsson, DF More by this author
Surakka, I More by this author
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Journal:
Nature genetics
Volume:
42
Issue:
5
Pages:
448-453
Publication date:
2010-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:d38f66d8-9b92-4389-b5d7-27762b56922f
Source identifiers:
54813
Local pid:
pubs:54813

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