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Evolution, revolution and heresy in the genetics of infectious disease susceptibility.

Abstract:

Infectious pathogens have long been recognized as potentially powerful agents impacting on the evolution of human genetic diversity. Analysis of large-scale case-control studies provides one of the most direct means of identifying human genetic variants that currently impact on susceptibility to particular infectious diseases. For over 50 years candidate gene studies have been used to identify loci for many major causes of human infectious mortality, including malaria, tuberculosis, human imm...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.2011.0275

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
367
Issue:
1590
Pages:
840-849
Publication date:
2012-03-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:d38c440f-6e29-4d44-8074-cf1a8546da19
Source identifiers:
254261
Local pid:
pubs:254261

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