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Dense genomic sampling identifies highways of pneumococcal recombination

Abstract:

Evasion of clinical interventions by Streptococcus pneumoniae occurs through selection of non-susceptible genomic variants. We report whole-genome sequencing of 3,085 pneumococcal carriage isolates from a 2.4-km 2 refugee camp. This sequencing provides unprecedented resolution of the process of recombination and its impact on population evolution. Genomic recombination hotspots show remarkable consistency between lineages, indicating common selective pressures acting at certain loci, particul...

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Publisher copy:
10.1038/ng.2895

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Publisher:
Nature Publishing Group
Journal:
Nature Genetics
Volume:
46
Issue:
3
Pages:
305-309
Publication date:
2014-01-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:d3894ad7-a812-4931-8341-cb5b9f19b491
Source identifiers:
472422
Local pid:
pubs:472422
Language:
English

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