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Journal article

Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection.

Abstract:

To determine the role that cellular immune responses play in the protection conferred by vaccination with attenuated SIVmac32H (pC8), we have attempted to deplete macaques of their CD8+ cells prior to challenge with wild-type SIVmac32H (pJ5). In two of four pC8-infected macaques, N109 and N112, a transient partial depletion of CD8+ cells by antibody treatment was achieved. On the day of challenge peripheral CD2+CD4-CD8+ cell counts were reduced by 92 and 95%, respectively, in animals N109 and...

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Publication status:
Published

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Publisher copy:
10.1089/aid.1998.14.1187

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Journal:
AIDS research and human retroviruses More from this journal
Volume:
14
Issue:
13
Pages:
1187-1198
Publication date:
1998-09-01
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
Language:
English
Keywords:
Pubs id:
pubs:25772
UUID:
uuid:d37b756e-715b-4e4f-830d-c4f2e308e08d
Local pid:
pubs:25772
Source identifiers:
25772
Deposit date:
2012-12-19

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