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Identification of common variants associated with human hippocampal and intracranial volumes

Abstract:

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonan...

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Publisher copy:
10.1038/ng.2250

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Journal:
Nature Genetics
Volume:
44
Issue:
5
Pages:
552-561
Publication date:
2012-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:d3767bc4-085c-4c77-a9fa-5a682279ff27
Source identifiers:
329890
Local pid:
pubs:329890
Language:
English

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