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Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis.

Abstract:

Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA), but little is understood about their citrullinated target antigens. We have detected a candidate citrullinated protein by immunoblotting lysates of monocytic and granulocytic HL-60 cells treated with peptidylarginine deiminase. In an initial screen of serum samples from four patients with RA and one control, a protein of molecular mass 47 kDa from monocytic HL-60s reacted with sera from the patients, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/ar1845

Authors


Kinloch, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Lundberg, K More by this author
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Arthritis Research Campaign More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Arthritis research and therapy Journal website
Volume:
7
Issue:
6
Pages:
R1421-R1429
Publication date:
2005
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:d36d7678-5073-4927-803f-e56ea2adba6c
Source identifiers:
227134
Local pid:
pubs:227134

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