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Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B.

Abstract:

Two splice variants of Nek2 kinase, a member of the NIMA-related family, have been identified as Nek2A and Nek2B. Nek2A regulates centrosome disjunction, spindle formation checkpoint signaling, and faithful chromosome segregation. A specific role for Nek2B has not yet been identified. Here, we have examined the distinct roles of Nek2A and Nek2B using timelapse video microscopy to follow the fate of cells progressing through the cell cycle in the absence of either Nek2A or Nek2B. We show that ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Biochimica et biophysica acta More from this journal
Volume:
1744
Issue:
2
Pages:
89-92
Publication date:
2005-06-01
DOI:
ISSN:
0006-3002

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