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Thesis

Theory and application of PBPK modelling in drug development: the double-edged sword of complexity

Abstract:

Physiologically-based pharmacokinetic modelling has become an integral part of model-informed drug development. However, the extensive structure and parameterisation of such models may give rise to issues with model identifiability, parameter estimation and model analysis techniques. In this thesis, we examine the strengths and limitations of whole-body physiologically-based pharmacokinetic models in regard to their complexity by investigating methods of extracting information from such model...

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Division:
MPLS
Department:
Mathematical Institute
Sub department:
Mathematical Institute
Research group:
Wolfson Centre for Mathematical Biology
Oxford college:
St Hugh's College
Role:
Author

Contributors

Institution:
Astra Zeneca
Role:
Contributor
ORCID:
0000-0001-9870-8418
Role:
Contributor
Role:
Contributor
Role:
Contributor
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Sub department:
Mathematical Institute
Research group:
Wolfson Centre for Mathematical Biology
Oxford college:
Brasenose College
Role:
Supervisor
ORCID:
0000-0002-6888-4362
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Grant:
EP/L016044/1
Programme:
Systems Approaches to Biomedical Science, Doctoral Training Centre, University of Oxford
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:

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