Journal article : Review
Endocrinology in the time of COVID-19: Clinical management of neuroendocrine neoplasms (NENs)
- Abstract:
- In viral pandemics, most specifically Covid-19, many patients with neuroendocrine neoplasms (NENs), including phaeochromocytomas, paragangliomas and medullary thyroid carcinoma, may develop Covid-19 in a mild or severe form, or be concerned about the influence of viral infection relative to their anti-tumoral therapy. In general, newly presenting patients should be assessed, and patients recently receiving chemotherapy, targeted therapy or radionuclide therapy, or showing tumour growth, should be closely followed. For previously diagnosed patients, who have indolent disease, some delay in routine follow-up or treatment may not be problematic. However, patients developing acute secretory syndromes due to functional neuroendocrine neoplasms (such as of the pancreas, intestine or lung), phaeochromocytomas and paragangliomas, will require prompt treatment. Patients with life-threatening Covid-19-related symptoms should be urgently treated and long-term anti-tumoral treatments may be temporarily delayed. In patients with especially aggressive NENs, a careful judgement should be made regarding the severity of any Covid-19 illness, tumour grade, and the immunosuppressant effects of any planned chemotherapy, immunotherapy (e.g. interferon-alpha), targeted therapy or related treatment. In other cases, especially patients with completely resected NENs, or who are under surveillance for a genetic disorder, a telephone or delayed consultation may be in order, balancing the risk of a delay against that of the possible development of Covid-19.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 390.1KB, Terms of use)
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- Publisher copy:
- 10.1530/eje-20-0424
Authors
- Publisher:
- Bioscientifica
- Journal:
- European Journal of Endocrinology More from this journal
- Volume:
- 183
- Issue:
- 2
- Pages:
- G79-G88
- Publication date:
- 2020-08-01
- Acceptance date:
- 2020-06-09
- DOI:
- EISSN:
-
1479-683X
- ISSN:
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0804-4643
- Pmid:
-
32554825
Terms of use
- Copyright holder:
- European Society of Endocrinology
- Copyright date:
- 2020
- Rights statement:
- © 2020 European Society of Endocrinology 2020.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Bioscientifica at: https://doi.org/10.1530/EJE-20-0424
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