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Journal article

Large clonal expansions of CD8+ T cells in acute infectious mononucleosis.

Abstract:

Primary infection with Epstein-Barr virus often results in the clinical syndrome of acute infectious mononucleosis (glandular fever). This illness is characterized by a striking lymphocytosis, the nature of which has been controversial. We show that large monoclonal or oligoclonal populations of CD8+ T cells account for a significant proportion of the lymphocytosis and provide molecular evidence that these populations have been driven by antigen. The results suggest that the selective and mas...

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Publication status:
Published

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Publisher copy:
10.1038/nm0896-906

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Journal:
Nature medicine
Volume:
2
Issue:
8
Pages:
906-911
Publication date:
1996-08-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:d35b7c4b-0ddb-4fef-b4b9-4381564eed36
Source identifiers:
15282
Local pid:
pubs:15282

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