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Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.

Abstract:

The insulin-like growth factor (IGF) type 1 receptor is required for growth, transformation, and protection from apoptosis. IGFs can enhance cell migration, which is known to be influenced via regulation of the E-cadherin/beta-catenin complex. We sought to investigate whether IGF-1 modulated the interaction between E-cadherin and beta-catenin in human colorectal cancer cells. We used the C10 cell line, which we established and have previously shown to lack adenomatous polyposis coli, E-cadher...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.210394297

Authors


Playford, MP More by this author
Bicknell, D More by this author
Bodmer, WF More by this author
Macaulay, VM More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
22
Pages:
12103-12108
Publication date:
2000-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d3567818-bf9c-42b4-b547-becc1e055ec1
Source identifiers:
177991
Local pid:
pubs:177991

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