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Evolution of primary microcephaly genes and the enlargement of primate brains

Abstract:

Brain size, in relation to body size, has varied markedly during the evolution of mammals. In particular, a large cerebral cortex is a feature that distinguishes humans from our fellow primates. Such anatomical changes must have a basis in genetic alterations, but the molecular processes involved have yet to be defined. However, recent advances from the cloning of two human disease genes promise to make inroads in this important area. Microcephalin (MCPH1) and Abnormal spindle-like microcepha...

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Publisher copy:
10.1016/j.gde.2005.04.009
Journal:
Current Opinion in Genetics and Development More from this journal
Volume:
15
Issue:
3 SPEC. ISS.
Pages:
241-248
Publication date:
2005-06-01
DOI:
ISSN:
0959-437X
Language:
English
Pubs id:
pubs:238356
UUID:
uuid:d3469756-f8ec-422f-8a3c-0e2159ce59db
Local pid:
pubs:238356
Source identifiers:
238356
Deposit date:
2013-11-16

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