Journal article
Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.
- Abstract:
-
Protein-lipid interactions regulate many membrane protein functions. Using a multiscale approach that combines coarse-grained and atomistic molecular dynamics simulations, we have predicted the binding site for the anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) on the Kir2.2 inwardly rectifying (Kir) potassium channel. Comparison of the predicted binding site to that observed in the recent PIP(2)-bound crystal structure of Kir2.2 reveals good agreement between simulation ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Biochemistry More from this journal
- Volume:
- 52
- Issue:
- 2
- Pages:
- 279-281
- Publication date:
- 2013-01-01
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:369967
- UUID:
-
uuid:d34506a3-9b4e-4699-ae7a-5c4ae75b1d47
- Local pid:
-
pubs:369967
- Source identifiers:
-
369967
- Deposit date:
-
2013-11-16
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- Copyright date:
- 2013
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