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Autophagy takes it all – autophagy inducers target immune aging

Abstract:

Autophagy, as the key nutrient recycling pathway, enables eukaryotic cells to adapt to surging cellular stress during aging and, thereby, delays age-associated deterioration. Autophagic flux declines with age and, in turn, decreases in autophagy contribute to the aging process itself and promote senescence. Here, we outline how autophagy regulates immune aging and discuss autophagy-inducing interventions that target senescent immune cells, which are major drivers of systemic aging. We examine...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dmm.049345

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0002-4077-7995
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Name:
Wellcome Trust
Grant:
103830/Z/14/Z
Publisher:
Company of Biologists
Journal:
Disease Models and Mechanisms More from this journal
Volume:
15
Issue:
1
Article number:
dmm049345
Publication date:
2022-01-31
Acceptance date:
2021-12-21
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
Language:
English
Keywords:
Pubs id:
1233255
Local pid:
pubs:1233255
Deposit date:
2022-01-24

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