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Journal article

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Abstract:

Nicastrin (NCSTN) is a component of the γ-secretase complex and therefore potentially a candidate risk gene for Alzheimer's disease. Here, we have developed a novel functional genomics methodology to express common locus haplotypes to assess functional differences. DNA recombination was used to engineer 5 bacterial artificial chromosomes (BACs) to each express a different haplotype of the NCSTN locus. Each NCSTN-BAC was delivered to knockout nicastrin (Ncstn(-/-)) cells and clonal NCSTN-BAC(+...

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Authors


Hamilton, G More by this author
Killick, R More by this author
Genetic, AERFADC More by this author
Translational, GRIC More by this author
Lambert, JC More by this author
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Journal:
Neurobiology of aging
Volume:
33
Issue:
8
Publication date:
2012-08-05
EISSN:
1558-1497
URN:
uuid:d3340a67-c947-4c6b-b42a-88f40474b239
Source identifiers:
359784
Local pid:
pubs:359784
Language:
English

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