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Genetic robustness and selection at the protein level for synonymous codons

Abstract:

Synonymous codons are neutral at the protein level, therefore natural selection at the protein level should have no effect on their frequencies. Synonymous codons, however, differ in their capacity to reduce the effects of errors: after mutation, certain codons keep on coding for the same amino acid or for amino acids with similar properties, while other synonymous codons produce very different amino acids. Therefore the impact of errors on a coding sequence (genetic robustness) can be measur...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Author's Original

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Publisher copy:
10.1111/j.1420-9101.2005.01029.x

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Institution:
University of Oxford
Oxford college:
St John's College
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Role:
Author
Publisher:
Blackwell Publishing Publisher's website
Journal:
Journal of Evolutionary Biology Journal website
Volume:
19
Issue:
2
Pages:
353-365
Publication date:
2006-03-06
DOI:
EISSN:
1420-9101
ISSN:
1010-061X
URN:
uuid:d32c68ff-f503-4159-832a-e32768136c50
Local pid:
ora:1724

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