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Journal article

Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation.

Abstract:

A number of models of spontaneous chronic intestinal inflammation in mice and rats have recently been developed. A characteristic of the majority of these models is that disease developed as a consequence of immune manipulations, suggesting a central role for the immune system in the regulation of intestinal inflammation. Analysis of cytokine patterns in disease showed elevations in TNF-alpha and IFN-gamma, characteristic of the T-helper-1 (Th1) pathway, implicating Th1 cells and their cytoki...

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Journal:
Therapeutic immunology
Volume:
2
Issue:
2
Pages:
115-123
Publication date:
1995-04-05
ISSN:
0967-0149
URN:
uuid:d327eb46-f9d9-468b-a34e-da61a8f89ed5
Source identifiers:
10266
Local pid:
pubs:10266

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