Genomic code for Sox10 activation reveals a key regulatory enhancer for cranial neural crest.

Journal article

The neural crest is a multipotent, stem cell-like population that migrates extensively in the embryo and forms a wide array of derivatives, ranging from neurons to melanocytes and cartilage. Analyses of the gene regulatory network driving neural crest development revealed Sox10 as one of the earliest neural crest-specifying genes, cell-autonomously driving delamination and directly regulating numerous downstream effectors and differentiation gene batteries. In search of direct inputs to the n...

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Authors: Betancur, P; Bronner-Fraser, M; Sauka-Spengler, T

• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 107
• Issue: 8
• Pages: 3570-3575
• Publication date: 2010-02-01
• DOI: 10.1073/pnas.0906596107
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Animals; Molecular Sequence Data; Xenopus; Multipotent Stem Cells; Enhancer Elements, Genetic; Humans; Rats; Genomics; Gene Expression Regulation, Developmental; Conserved Sequence; Neural Crest; Chick Embryo; Skull; Base Sequence; Transcriptional Activation; Gene Regulatory Networks; Mice; SOXB1 Transcription Factors