Journal article

Systematic identification of structure-specific protein–protein interactions

Abstract:: The physical interactome of a protein can be altered upon perturbation, modulating cell physiology and contributing to disease. Identifying interactome differences of normal and disease states of proteins could help understand disease mechanisms, but current methods do not pinpoint structure-specific PPIs and interaction interfaces proteome-wide. We used limited proteolysis–mass spectrometry (LiP–MS) to screen for structure-specific PPIs by probing for protease susceptibility changes of prote...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Holfeld, A., Schuster, D., Sesterhenn, F., Gillingham, A. K., Stalder, P., Haenseler, W., Barrio-Hernandez, I., Ghosh, D., Vowles, J., Cowley, S. A., Nagel, L., Khanppnavar, B., Serdiuk, T., Beltrao, P., Korkhov, V. M., Munro, S., Riek, R., de Souza, N., & Picotti, P. (2024). Systematic identification of structure-specific protein–protein interactions. Molecular Systems Biology, 20(6), 651–675.

MLA Style

Holfeld, A., et al. “Systematic Identification of Structure-Specific Protein–Protein Interactions.” Molecular Systems Biology, vol. 20, no. 6, Springer, 2024, pp. 651–75.

Chicago Style

Holfeld, A, D Schuster, F Sesterhenn, AK Gillingham, P Stalder, W Haenseler, I Barrio-Hernandez, et al. 2024. “Systematic Identification of Structure-Specific Protein–Protein Interactions.” Molecular Systems Biology 20 (6): 651–75.
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Publisher copy:: 10.1038/s44320-024-00037-6

Authors

+ Holfeld, A More by this author

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+ Schuster, D More by this author

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Author

ORCID:

0000-0001-6611-8237

+ Sesterhenn, F More by this author

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Author

+ Gillingham, AK More by this author

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Author

ORCID:

0009-0000-3835-2333

+ Stalder, P More by this author

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Bibliographic Details

Publisher:: Springer
Journal:: Molecular Systems Biology More from this journal
Volume:: 20
Issue:: 6
Pages:: 651-675
Publication date:: 2024-05-03
Acceptance date:: 2024-04-15
DOI:: 10.1038/s44320-024-00037-6
EISSN:: 1744-4292

Item Description

Language:: English
Keywords:: Structural Proteomics

Protein–protein Interactions

Structure-Specific Interactions

Mass Spectrometry

Limited Proteolysis
Source identifiers:: 2015637
Deposit date:: 2024-06-03

Terms of use

Copyright date:: 2024

Licence:: CC Attribution (CC BY)

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