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The interaction between the Marek’s Disease Virus (MDV) neurovirulence factor pp14 and the host transcription factor, CREB3

Abstract:

Marek’s Disease Virus (MDV) induces a wide range of neurological syndromes in susceptible hosts; however, the mechanisms behind the MDV-induced neuropathology are still poorly understood. The immediate-early 14kDa phosphoprotein, pp14, is associated with the neurovirulence phenotype of the virus. Yeast-two-hybrid screening identified the ER-bound transcription regulator, human CREB3 (cAMP Response Element-Binding protein), as an interacting partner of pp14, and fluorescence colocalisation ...

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Division:
MSD
Department:
NDM
Role:
Author

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Supervisor
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Supervisor
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Supervisor
Biotechnology and Biological Sciences Research Council More from this funder
The Pirbright Institute More from this funder
University of Oxford More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:d2fc6bd4-bc3a-4a37-924b-86881096a9b5
Deposit date:
2018-06-10

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