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Necrotic granulomatous pseudotumours in bilateral resurfacing hip arthoplasties: evidence for a type IV immune response.

Abstract:

Clinical, radiological and histological findings were analysed in four patients who developed bilateral pseudotumours following metal-on-metal (MoM) resurfacing arthroplasties of both hips. Using a panel of monoclonal antibodies directed against HLA-DR, macrophages (CD14, CD68), dendritic cells (DC-SIGN, S100, CD11c), B cells (CD20), and T cells (CD3, CD4, CD8), the nature of the heavy inflammatory response seen in these cases was examined. Bilateral masses developed in periprosthetic soft ti...

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Publication status:
Published

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Publisher copy:
10.1007/s00428-008-0659-9

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Vlychou, M More by this author
Whitwell, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Virchows Archiv : an international journal of pathology
Volume:
453
Issue:
5
Pages:
529-534
Publication date:
2008-11-05
DOI:
EISSN:
1432-2307
ISSN:
0945-6317
URN:
uuid:d2f6aa5e-4b97-4b65-8e5c-71a6295dbfd0
Source identifiers:
62573
Local pid:
pubs:62573

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