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Optimising controlled human malaria infection studies using cryopreserved p. falciparum parasites administered by needle and syringe

Abstract:

Background: Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have mostly been conducted using the bite of infected mosquitoes, restricting the number of trial sites that can perform CHMI studies. Aseptic, cryopreserved P. falciparum sporozoites (PfSPZ Challenge) provide a potentially more accurate, reproducible and practical alternative, allowing a known n... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
084113/Z/07/Z
More from this funder
Name:
National Institute of Health Research Oxford Biomedical Research Centre
Grant:
A91301
Publisher:
Public Library of Science
Journal:
PloS One More from this journal
Volume:
8
Issue:
6
Article number:
e65960
Publication date:
2013-06-18
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Pubs id:
pubs:407956
UUID:
uuid:d2f3d30c-c2b1-4eb3-bd89-da36b875a745
Local pid:
pubs:407956
Source identifiers:
407956
Deposit date:
2013-11-16

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