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Journal article

Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression.

Abstract:

BACKGROUND AND PURPOSE: In muscle-invasive bladder cancer there is an urgent need to identify relatively non-toxic radiosensitising agents for use in elderly patients. Histone deacetylase inhibitors radiosensitise tumour cells but not normal cells in vitro and variously downregulate DNA damage signalling, homologous recombination (HR) and non-homologous end-joining (NHEJ) repair proteins. We investigated panobinostat (PAN) as a potential radiosensitiser in bladder cancer cells. MATERIALS AND ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology More from this journal
Volume:
108
Issue:
3
Pages:
429-433
Publication date:
2013-09-01
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
Language:
English
Keywords:
Pubs id:
pubs:417051
UUID:
uuid:d2d73ac8-cce5-466c-adfb-2756555f229a
Local pid:
pubs:417051
Source identifiers:
417051
Deposit date:
2013-11-17

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