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Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients.

Abstract:

The effects of the immunosuppressant Cyclosporin A (CsA) on T cell activation in vivo and in vitro were examined using the monoclonal antibody, anti-Tac, for interleukin 2 (IL-2) receptors and 3.9C2, for a peptide fragment of human IL-2. Peripheral blood lymphocytes (PBL) were stimulated with PHA in the presence of CsA. The expression of IL-2 receptors and production of IL-2 were reduced. PBL from CsA-treated MS patients had significantly lower proportions of Tac+ cells compared with untreate...

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Publication status:
Published

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Authors


Calder, VL More by this author
Bellamy, AS More by this author
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Journal:
Clinical and experimental immunology
Volume:
70
Issue:
3
Pages:
570-577
Publication date:
1987-12-05
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:d2cdad6e-acee-4db7-a653-4e086228e9ab
Source identifiers:
481793
Local pid:
pubs:481793

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