- Abstract:
-
Purpose
To investigate the precise mechanism of recognition and processing of ionizing radiation (IR)-induced complex DNA damage (CDD), where two or more DNA lesions are in close proximity, in cellular DNA which is packaged with histones to form chromatin.
Methods and Materials
HeLa and oropharyngeal squamous cell carcinoma (UMSCC74A and UMSCC6) cells were irradiated with high linear energy transfer (LET) a-particles or protons, versus low-LET protons and X rays. ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.9mb)
-
- Publisher copy:
- 10.1016/j.ijrobp.2017.11.012
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- International Journal of Radiation Oncology, Biology, Physics Journal website
- Volume:
- 100
- Issue:
- 3
- Pages:
- 776-784
- Publication date:
- 2017-11-14
- Acceptance date:
- 2017-11-07
- DOI:
- EISSN:
-
1879-355X
- ISSN:
-
0360-3016
- Pubs id:
-
pubs:823349
- URN:
-
uri:d2bf3848-539b-4a27-b4c8-7c744f4a51a4
- UUID:
-
uuid:d2bf3848-539b-4a27-b4c8-7c744f4a51a4
- Local pid:
- pubs:823349
- Language:
- English
- Keywords:
- Copyright holder:
- Hill et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Complex DNA damage induced by high linear energy transfer alpha-particles and protons triggers a specific cellular DNA damage response
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North West Cancer Research
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