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Complex DNA damage induced by high linear energy transfer alpha-particles and protons triggers a specific cellular DNA damage response

Abstract:

Purpose

To investigate the precise mechanism of recognition and processing of ionizing radiation (IR)-induced complex DNA damage (CDD), where two or more DNA lesions are in close proximity, in cellular DNA which is packaged with histones to form chromatin.

Methods and Materials

HeLa and oropharyngeal squamous cell carcinoma (UMSCC74A and UMSCC6) cells were irradiated with high linear energy transfer (LET) a-particles or protons, versus low-LET protons and X rays. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ijrobp.2017.11.012

Authors


Carter, RJ More by this author
Nickson, CM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Kacperek, A More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
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North West Cancer Research More from this funder
Cancer Research UK More from this funder
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Radiation Oncology, Biology, Physics Journal website
Volume:
100
Issue:
3
Pages:
776-784
Publication date:
2017-11-14
Acceptance date:
2017-11-07
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Pubs id:
pubs:823349
URN:
uri:d2bf3848-539b-4a27-b4c8-7c744f4a51a4
UUID:
uuid:d2bf3848-539b-4a27-b4c8-7c744f4a51a4
Local pid:
pubs:823349
Language:
English
Keywords:

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