Journal article
Complex DNA damage induced by high linear energy transfer alpha-particles and protons triggers a specific cellular DNA damage response
- Abstract:
-
Purpose
To investigate the precise mechanism of recognition and processing of ionizing radiation (IR)-induced complex DNA damage (CDD), where two or more DNA lesions are in close proximity, in cellular DNA which is packaged with histones to form chromatin.
Methods and Materials
HeLa and oropharyngeal squamous cell carcinoma (UMSCC74A and UMSCC6) cells were irradiated with high linear energy transfer (LET) a-particles or protons, versus low-LET protons and X rays. ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 1.9MB)
-
- Publisher copy:
- 10.1016/j.ijrobp.2017.11.012
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
North West Cancer Research
More from this funder
Cancer Research UK
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- International Journal of Radiation Oncology, Biology, Physics Journal website
- Volume:
- 100
- Issue:
- 3
- Pages:
- 776-784
- Publication date:
- 2017-11-14
- Acceptance date:
- 2017-11-07
- DOI:
- EISSN:
-
1879-355X
- ISSN:
-
0360-3016
- Pmid:
-
29413288
- Source identifiers:
-
823349
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:823349
- UUID:
-
uuid:d2bf3848-539b-4a27-b4c8-7c744f4a51a4
- Local pid:
- pubs:823349
- Deposit date:
- 2018-05-14
Terms of use
- Copyright holder:
- Hill et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record