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Single-molecule studies of DNA-binding proteins in live bacteria

Abstract:

Protein-DNA interactions are critical to many important biological functions, from transcription to DNA replication. To better understand these processes we need to look at molecular details, such as the stoichiometries and binding kinetics of these proteins. However, focusing on the molecular level can miss the bigger picture; we also need to understand how protein-DNA interactions shape the organisation of chromosomes and cause phenotypical changes over the whole cell.

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Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author

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Role:
Supervisor
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Name:
Engineering & Physical Sciences Research Council
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:d2b6ad0a-0fd4-4742-9ca2-dc13ba95f267
Deposit date:
2016-09-01

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